Article

B cells from aged mice do not have intrinsic defects in affinity maturation

2023-04-25

Abstract excerpt

Affinity maturation, the progressive increase in serum antibody affinity after vaccination, is an essential process that contributes to an effective humoral response against vaccines and infections. Germinal centres (GCs) are key for affinity maturation, as they are where B cells undergo somatic hypermutation of their immunoglobulin genes in the dark zone, before going through positive selection in the light zone...

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Literature Corpus work: 081cdb7a-88e9-5267-9536-3a519232a279
DOI: 10.1101/2023.04.24.538044

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