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Article

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response.

The EMBO journal - 2 Jun 1997

Smith K G, Light A, Nossal G J, Tarlinton D M

Abstract excerpt

Immunization with protein-containing antigens results in two types of antigen-specific B cell: antibody forming cells (AFCs) producing antibody of progressively higher affinity and memory lymphocytes capable of producing high affinity antibody upon re-exposure to antigen. The issue of the inter-relationship between affinity maturation of memory B cells and AFCs was addressed through analysis of single,...

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Identifiers

PMID: 9214617
DOI: 10.1093/emboj/16.11.2996
PMCID: PMC1169918

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