Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.

European journal of immunology - 1 Aug 2000

Wang Y, Huang G, Wang J, Molina H, Chaplin D D, Fu Y X

Abstract excerpt

Whether germinal centers (GC) with follicular dendritic cell (FDC) clusters are the essential sites for affinity maturation of immunoglobulin is still controversial. To re-evaluate the role of GC / FDC in affinity maturation and somatic mutation in a defined antigen system, lymphotoxin-alpha(- / -) and TNF receptor I(- / -) mice, lacking GC / FDC, were immunized with (4-hydroxy-3-nitrophenyl) acetyl-sheep RBC...

Topics

Animals
Antibody Affinity
Antibody Formation
Antigens
Antigens, CD
Base Sequence
Dendritic Cells
Germinal Center
Immunoglobulin Class Switching
Lymphotoxin-alpha
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Receptors, Tumor Necrosis Factor

Receptors, Tumor Necrosis Factor, Type I

Source

Identifiers

PMID: 10940914
DOI: 10.1002/1521-4141(2000)30:8<2226::AID-IMMU2226>3.0.CO;2-5

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.PMID 10940914Read ↗

Ig VH hypermutation is absent in the germinal centers of aged mice.Semantic proximity Read ↗

B cells from aged mice do not have intrinsic defects in affinity maturationSemantic proximity Read ↗

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal CentersSemantic proximity Read ↗

Affinity‐based selection and the germinal center responseSemantic proximity Read ↗

Self-Reactive B Cells in the Germinal Center ReactionSemantic proximity Read ↗

Lymph node germinal centers form in the absence of follicular dendritic cell networks.Semantic proximity Read ↗

Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations.Semantic proximity Read ↗

Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response.Semantic proximity Read ↗

Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.Semantic proximity Read ↗

Affinity maturation and class switching.Semantic proximity Read ↗

Analysis of the germinal center reaction and in vivo long-lived plasma cells.Semantic proximity Read ↗

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.