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Article

Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.

European journal of immunology - 1 Aug 2000

Wang Y, Huang G, Wang J, Molina H, Chaplin D D, Fu Y X

Abstract excerpt

Whether germinal centers (GC) with follicular dendritic cell (FDC) clusters are the essential sites for affinity maturation of immunoglobulin is still controversial. To re-evaluate the role of GC / FDC in affinity maturation and somatic mutation in a defined antigen system, lymphotoxin-alpha(- / -) and TNF receptor I(- / -) mice, lacking GC / FDC, were immunized with (4-hydroxy-3-nitrophenyl) acetyl-sheep RBC...

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Share to Antibody Affinity
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10940914
DOI: 10.1002/1521-4141(2000)30:8<2226::AID-IMMU2226>3.0.CO;2-5

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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