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Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocations

2025-07-27

Abstract excerpt

Centromeres are among the most diverse and dynamically evolving regions of the human genome and are commonly affected in various human cancers. However, organized into highly repetitive α-satellite higher-order repeats (HORs), human centromere sequences have long resisted detailed genomic analysis. Although the development of long-read sequencing platforms has enabled the analysis of complete centromere sequences,...

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Literature Corpus work
081c5d91-46ae-5597-8b3a-5f8434ccd903
DOI
10.1101/2025.07.26.666712
Open publication

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Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocationsDOI 10.1101/2025.07.26.666712
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