Article

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

2021-03-03

Abstract excerpt

<h4>Background and Aims</h4> Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire ‘gain-of-function’ isoDGR motifs that might play a role in atherosclerotic pathology. <h4>Methods</h4> IsoDGR-specific mAb were generated and used for ELISA-based measureme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0815af65-2b5e-58e6-81bc-609d51b544bc
DOI: 10.1101/2021.03.02.21252419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosisDOI 10.1101/2021.03.02.21252419Read

IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier BreakdownSemantic proximity Read

The Matrisome during Aging and Longevity: A Systems-Level Approach towards Defining Matreotypes Promoting Healthy AgingSemantic proximity Read

Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and diseaseSemantic proximity Read

The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy AgingSemantic proximity Read

Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and AtherosclerosisSemantic proximity Read

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological AgingSemantic proximity Read

Discovery of Diagnostic and Therapeutic Targets For Vascular Injury Induced By Methylglyoxal Using ProteomicsSemantic proximity Read

IgG Propels Atherosclerosis by Noncanonically Activating MacrophagesSemantic proximity Read

SAMD1 Distribution Patterns in Mouse Atherosclerosis Models Suggest Roles in LDL Retention, Antigen Presentation, and Cell Phenotype ModulationSemantic proximity Read

Increased expression of <i>Cd74</i> and MHC II genes by aortic macrophages links atherosclerosis with aging in miceSemantic proximity Read

Histone functions as a cell-surface receptor for AGEsSemantic proximity Read

Inflammatory Triggers, Cell Death, Membrane Damage and Lipid Asymmetry That Shape Procoagulant Surfaces for Amyloidogenic MicroclottingSemantic proximity Read