Article

IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown

2025-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Brain aging is characterized by progressive breakdown of the blood-brain barrier (BBB), which correlates with neuroinflammation and cognitive decline. Emerging evidence implicates degenerative modifications of the vascular proteins as a key driver of BBB dysfunction. In particular, spontaneous deamidation of Asp-Gly-Arg (NGR) motifs generates isoAsp-Gly-Arg (isoDGR) sequences that structurally m...

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Literature Corpus work: b44823b6-a85b-5bad-9288-dbdcb717d3d5
DOI: 10.1101/2025.07.08.663800

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