Article

Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis

2026-07-08

Abstract excerpt

<h4>Background</h4> Age is the most important risk factor for coronary artery disease (CAD) independent of traditional risk factors. Aging induces classic pro-inflammatory and prothrombotic vascular phenotypic changes whose molecular mediators remain poorly understood. Medin is a common cleavage product protein that accumulates in vasculature with aging and shown to cause endothelial dysfunction. Its role in CAD...

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Literature Corpus work: a5255694-aefc-56d1-9447-9ffcf3d904a4
DOI: 10.64898/2026.07.02.736227

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