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Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

21 Dec 2023

Abstract excerpt

Impaired extracellular matrix (ECM) remodeling is a hallmark of many chronic inflammatory disorders that can lead to cellular dysfunction, aging, and disease progression. The ECM of the aged heart and its effects on cardiac cells during chronological and pathological aging are poorly understood across species. For this purpose, we first used mass spectrometry-based proteomics to quantitatively characterize...

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PMID: 38141925
DOI: 10.1016/j.mcpro.2023.100706

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