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Article

Histone functions as a cell-surface receptor for AGEs

27 May 2022

Abstract excerpt

Reducing sugars can covalently react with proteins to generate a heterogeneous and complex group of compounds called advanced glycation end products (AGEs). AGEs are generally considered as pathogenic molecules, mediating a pro-inflammatory response and contributing to the development of a number of human diseases. However, the intrinsic function of AGEs remains to be elucidated. We now provide multiple lines of...

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PMID: 35624109
DOI: 10.1038/s41467-022-30626-8

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