Article

SAMD1 Distribution Patterns in Mouse Atherosclerosis Models Suggest Roles in LDL Retention, Antigen Presentation, and Cell Phenotype Modulation

2021-09-12

Abstract excerpt

The theory that lesions formed by retention of circulating LDL can then progress to complicated atherosclerotic lesions has been a subject of debate, as has the mechanism of retention. In earlier work, we identified SAMD1, a protein expressed by intimal smooth muscle cells in human lesions that appears to irreversibly bind apoB-Lps in extracellular matrix near the lumen. We hypothesized this binding could contribu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a968a36b-3894-5ba6-b1ee-971dfe304e26
DOI: 10.1101/2021.09.12.459413

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SAMD1 Distribution Patterns in Mouse Atherosclerosis Models Suggest Roles in LDL Retention, Antigen Presentation, and Cell Phenotype ModulationDOI 10.1101/2021.09.12.459413Read

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosisSemantic proximity Read

LRG1 promotes atherosclerosis by activating macrophagesSemantic proximity Read

The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions.Semantic proximity Read

Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppressionSemantic proximity Read

Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular LesionsSemantic proximity Read

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis modelSemantic proximity Read

Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease.Semantic proximity Read

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression ProfilingSemantic proximity Read

Increased Cell and Matrix Accumulation During Atherogenesis in Mice With Vessel Wall–Specific Deletion of Discoidin Domain Receptor 1Semantic proximity Read

Single-cell multimodal profiling of atherosclerosis identifies CD200 as a cell surface lineage marker of vascular smooth muscle cells and their derived cellsSemantic proximity Read

A major role for RCAN1 in atherosclerosis progression.Semantic proximity Read

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.Semantic proximity Read