Back to search

Article

Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesis

2020-11-06

Abstract excerpt

Aurora kinase A (AURKA) is a conserved kinase that plays crucial roles in numerous cellular processes. Although AURKA overexpression is frequent in human cancers, its pleiotropic functions and complex spatiotemporal regulation have presented challenges in its therapeutic targeting. An essential step to overcome these challenges is the identification of the full range of AURKA regulators and substrates, which are o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
08080c1a-c6ae-5097-a63f-09011a0734c6
DOI
10.1101/2020.11.05.370320
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesisDOI 10.1101/2020.11.05.370320
Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious DiseasesSemantic proximity
Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity
Aurora Kinases: Their Role in Cancer and Cellular ProcessesSemantic proximity
Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycleSemantic proximity
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity
Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.Semantic proximity
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancerSemantic proximity
A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stabilitySemantic proximity
Aurora kinases signaling in cancer: from molecular perception to targeted therapiesSemantic proximity
Aurora Kinases as Therapeutic Targets in Head and Neck CancerSemantic proximity
The Aurora kinases: role in cell transformation and tumorigenesis.Semantic proximity
INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.Semantic proximity
Select a neighboring publication to make it the new centre.