Article
Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
2021-01-01
Abstract excerpt
Aurora kinase A (AURKA) is a major mitotic regulatory kinase required for mitotic entry, the formation of a bipolar mitotic spindle, and the completion of cytokinesis. In recent years AURKA has been identified as an upstream regulator for many interphase functions such as cilia disassembly and mitochondrial fragmentation. AURKA is overexpressed in many tumours and has a pivotal role in the acquisition of malignant...
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Identifiers and source
- Literature Corpus work
- d8673b49-f772-5079-8f6e-e0d3cea5d10e
- DOI
- 10.17863/cam.69713