Article
INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.
Journal of cell science - 15 Jan 2015
Plotnikova Olga V, Seo Seongjin, Cottle Denny L, Conduit Sarah, Hakim Sandra, Dyson Jennifer M, Mitchell Christina A, Smyth Ian M
Abstract excerpt
Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood. Here, we describe an interaction between INPP5E and AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly, and we show that this interaction is important for the stability of primary cilia. Furthermore,...
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