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Aurora Kinases as Therapeutic Targets in Head and Neck Cancer

1 Sept 2022

Abstract excerpt

ABSTRACT: The Aurora kinases (AURKA and AURKB) have attracted attention as therapeutic targets in head and neck squamous cell carcinomas. Aurora kinases were first defined as regulators of mitosis that localization to the centrosome (AURKA) and centromere (AURKB), governing formation of the mitotic spindle, chromatin condensation, activation of the core mitotic kinase CDK1, alignment of chromosomes at metaphase,...

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PMID: 36165728
DOI: 10.1097/ppo.0000000000000614

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