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Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer

13 May 2021

Abstract excerpt

The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the gene locus, increased transcription or post-translational modifications. Several inhibitors of Aurora-A activity have been developed as anti-cancer agents and are under evaluation in clinical trials. Although the well-known...

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PMID: 33981003
DOI: 10.1038/s41388-021-01766-w

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