Article
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome.
Nature biomedical engineering - 1 May 2023
Silva-Pinheiro Pedro, Mutti Christian D, Van Haute Lindsey, Powell Christopher A, Nash Pavel A, Turner Keira, Minczuk Michal
Abstract excerpt
The development of curative treatments for mitochondrial diseases, which are often caused by mutations in mitochondrial DNA (mtDNA) that impair energy metabolism and other aspects of cellular homoeostasis, is hindered by an incomplete understanding of the underlying biology and a scarcity of cellular and animal models. Here we report the design and application of a library of double-stranded-DNA deaminase-derived...
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