Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.

BioMed research international - 1 Jan 2022

Zhou Yunting, Wang Yuming, Ni Chengming, Wang Huiying, Zhou Junming, Wan Bingying, Li Huiqin, Li Fengfei, Huang Rong, Xu Wei, Shan Ting, Cai Tingting, Kong Xiaoceng, Liu Bingli, Liu Xiaomei, Sun Zilin, Ma Jianhua

Abstract excerpt

Aims: We explored whether and how perilipin 2 (Plin2) protected islets against lipotoxicity-induced islet dysfunction by regulating islet stellate cells (ISCs) activation. Methods: Six-week-old male rats were given a high-fat diet or a control diet for 28 weeks. Glucose metabolic phenotypes were assessed using glucose/insulin tolerance tests, masson, and immunohistochemical staining. ISCs activation levels were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibrosis
Share to Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 35845956
DOI: 10.1155/2022/4581405
PMCID: PMC9279040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.PMID 35845956Read ↗

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changesSemantic proximity Read ↗

Screening and Identification of Key Genes for Activation of Islet Stellate CellSemantic proximity Read ↗

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell DysfunctionSemantic proximity Read ↗

Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis.Semantic proximity Read ↗

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.Semantic proximity Read ↗

Islet inflammation in type 2 diabetes and physiologySemantic proximity Read ↗

Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice.Semantic proximity Read ↗

Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic PancreatitisSemantic proximity Read ↗

Metformin's Effect on Non-Alcoholic Fatty Liver Disease through the miR-200a-5p and AMPK/SERCA2b PathwaySemantic proximity Read ↗

Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological featuresSemantic proximity Read ↗

Influence of metabolically compromised Adipose derived stem cell secretome on islet differentiation and functionality.Semantic proximity Read ↗

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic isletsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.