Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.

Stem cell reviews and reports - 1 Aug 2020

Singh Pratibha, Kacena Melissa A, Orschell Christie M, Pelus Louis M

Abstract excerpt

Aging impairs the regenerative potential of hematopoietic stem cells (HSC) and skews differentiation towards the myeloid lineage. The bone marrow (BM) microenvironment has recently been suggested to influence HSC aging, however the mechanisms whereby BM stromal cells mediate this effect is unknown. Here we show that aging-associated decreased expression of CXCR4 expression on BM mesenchymal stem cells (MSC) plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Colony-Forming Units Assay

Share to Free Radical Scavengers

Share to Hematopoietic Stem Cells

Share to Mesenchymal Stem Cells

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 32418119
DOI: 10.1007/s12015-020-09974-9
PMCID: PMC7395885

Genes

MSC
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.PMID 32418119Read ↗

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read ↗

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell AgingSemantic proximity Read ↗

Bone marrow derived mesenchymal stem cells from aged mice have reduced wound healing, angiogenesis, proliferation and anti‐apoptosis capabilitiesSemantic proximity Read ↗

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche.Semantic proximity Read ↗

Cell intrinsic alterations underlie hematopoietic stem cell agingSemantic proximity Read ↗

Secretome of Young Mesenchymal Stromal Cells Rejuvenates Aged Mesenchymal Stromal Cells by Normalizing Their Phenotype and Restoring Their Differentiation Profile.Semantic proximity Read ↗

Mechanisms of hematopoietic stem cell aging.Semantic proximity Read ↗

Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cellsSemantic proximity Read ↗

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice.Semantic proximity Read ↗

Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells.Semantic proximity Read ↗

The role of GATA4 in mesenchymal stem cell senescence: A new frontier in regenerative medicineSemantic proximity Read ↗

Long‐term repopulation of aged bone marrow stem cells using young Sca‐1 cells promotes aged heart rejuvenationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.