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Causes and Mechanisms of Hematopoietic Stem Cell Aging

13 Mar 2019

Abstract excerpt

Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells throughout the lifetime of an organism. Recent reports have suggested that HSCs are susceptible to age-related stress and gradually lose their self-renewal and regeneration capacity with aging. HSC aging is driven by cell-intrinsic and...

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PMID: 30871268
DOI: 10.3390/ijms20061272

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