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Laboratory evolution of <i>Mycobacterium smegmatis</i> in the presence of a fluoroquinolone leads to extreme drug resistance phenotype through the over-expression of <i>Msmeg_5659-61 efflux pump.</i>

2022-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the primary source of drug resistance, absence of mutations in these genes in many clinical strains suggests additional mechanisms of r...

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Literature Corpus work
07d761a8-505d-5c3f-8307-06e0b018d3ac
DOI
10.1101/2022.12.18.519879
Open publication

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Laboratory evolution of <i>Mycobacterium smegmatis</i> in the presence of a fluoroquinolone leads to extreme drug resistance phenotype through the over-expression of <i>Msmeg_5659-61 efflux pump.</i>DOI 10.1101/2022.12.18.519879
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