Article
Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient.
Genome biology - 7 Nov 2014
Eldholm Vegard, Norheim Gunnstein, von der Lippe Bent, Kinander Wibeke, Dahle Ulf R, Caugant Dominique A, Mannsåker Turid, Mengshoel Anne Torunn, Dyrhol-Riise Anne Ma, Balloux Francois
Abstract excerpt
BACKGROUND: Mycobacterium tuberculosis is characterized by a low mutation rate and a lack of genetic recombination. Yet, the rise of extensively resistant strains paints a picture of a microbe with an impressive adaptive potential. Here we describe the first documented case of extensively drug-resistant tuberculosis evolved from a susceptible ancestor within a single patient. RESULTS: Genome sequences of nine...
Topics
- Anti-Infective Agents
- Evolution, Molecular
- Extensively Drug-Resistant Tuberculosis
- Genome, Bacterial
- High-Throughput Nucleotide Sequencing
- Humans
- Mutation
- Mycobacterium tuberculosis
- Phylogeny