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Article

Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient.

Genome biology - 7 Nov 2014

Eldholm Vegard, Norheim Gunnstein, von der Lippe Bent, Kinander Wibeke, Dahle Ulf R, Caugant Dominique A, Mannsåker Turid, Mengshoel Anne Torunn, Dyrhol-Riise Anne Ma, Balloux Francois

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis is characterized by a low mutation rate and a lack of genetic recombination. Yet, the rise of extensively resistant strains paints a picture of a microbe with an impressive adaptive potential. Here we describe the first documented case of extensively drug-resistant tuberculosis evolved from a susceptible ancestor within a single patient. RESULTS: Genome sequences of nine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25418686
DOI: 10.1186/s13059-014-0490-3
PMCID: PMC4223161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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