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Disruption of RCAN1.4 Expression Mediated by YY1/HDAC2 Modulates Chronic Renal Allograft Interstitial Fibrosis

2023-05-11

Abstract excerpt

Chronic allograft dysfunction (CAD) is a major factor that hinders kidney transplant survival in the long run. Epithelial-mesenchymal transition (EMT) has been confirmed to significantly contribute to interstitial fibrosis/tubular atrophy (IF/TA), which is the main histopathological feature of CAD. Aberrant expression of regulator of calcineurin 1 (RCAN1), recognized as an endogenous inhibitor of the calcineurin p...

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Literature Corpus work
e8265b8c-65f6-5169-b203-bea98c4bbcd1
DOI
10.21203/rs.3.rs-2799463/v1
Open publication

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Disruption of RCAN1.4 Expression Mediated by YY1/HDAC2 Modulates Chronic Renal Allograft Interstitial FibrosisDOI 10.21203/rs.3.rs-2799463/v1
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