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Article

Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus.

PloS one - 1 Jan 2012

Veron Delma, Villegas Guillermo, Aggarwal Pardeep Kumar, Bertuccio Claudia, Jimenez Juan, Velazquez Heino, Reidy Kimberly, Abrahamson Dale R, Moeckel Gilbert, Kashgarian Michael, Tufro Alda

Abstract excerpt

Podocyte or endothelial cell VEGF-A knockout causes thrombotic microangiopathy in adult mice. To study the mechanism involved in acute and local injury caused by low podocyte VEGF-A we developed an inducible, podocyte-specific VEGF-A knockdown mouse, and we generated an immortalized podocyte cell line (VEGF(KD)) that downregulates VEGF-A upon doxycycline exposure. Tet-O-siVEGF:podocin-rtTA mice express VEGF shRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22808199
DOI: 10.1371/journal.pone.0040589
PMCID: PMC3396653

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