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Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

20 Feb 2009

Abstract excerpt

Dietary restriction (DR) increases mammalian lifespan and decreases susceptibility to many age-related diseases. Lifespan extension due to DR is conserved across a wide range of species. Recent research has focused upon genetically tractable model organisms such as C. elegans to uncover the genetic mechanisms that regulate the response to DR, in the hope that this information will provide insight into the...

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PMID: 19229346
DOI: 10.1371/journal.pone.0004535

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