Article
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
2019-10-04
Abstract excerpt
The decline in early life mortality since the 1950s has resulted in dramatic demographic shift towards aged population. Aging manifests as a decline in health, multiple organ dysfunction and increased vulnerability to diseases, which degrades quality of life. A verity of genetic and pharmacological interventions, mostly from non-vertebrate models, have been identified that can enhance lifespan. Whether these inter...
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Identifiers and source
- Literature Corpus work
- c6d6c5cf-3dcd-51b1-9e2b-64a23a2fa3f4
- DOI
- 10.1101/779157