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Tipepidine extends median lifespan in Caenorhabditis elegans.

Biomedical research (Tokyo, Japan) - 1 Jan 2026

Nakajima Mitsunari, Shimizu Ren, Sawamoto Atsushi, Okuyama Satoshi

Abstract excerpt

Many scientists are interested in anti-aging interventions and seek to identify anti-aging medicines. In our previous study, we reported that an antitussive drug, tipepidine (TIP), activates AMP-activated protein kinase (AMPK) and improves glucose intolerance in high-fat diet-induced obese mice. Activation of AMPK has been reported to extend lifespan in various experimental organisms, including Caenorhabditis...

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PMID: 42543565
DOI: 10.2220/biomedres.47.141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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