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Article

Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.

Cell metabolism - 5 Sept 2012

Xie Meng, Roy Richard

Abstract excerpt

Cells have evolved numerous mechanisms to circumvent stresses caused by the environment, and many of them are regulated by the AMP-activated kinase (AMPK). Unlike most organisms, C. elegans AMPK-null mutants are viable, but they die prematurely in the "long-lived" dauer stage due to exhaustion of triglyceride stores. Using a genome-wide RNAi approach, we demonstrate that the disruption of genes that increase...

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PMID: 22921415
DOI: 10.1016/j.cmet.2012.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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