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Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension

30 Jul 2020

Abstract excerpt

Pharmacological modulation of class I histone deacetylases (HDAC) has been evaluated as a therapeutic strategy for pulmonary hypertension (PH) in experimental models of PH. However, information of their expression, regulation and transcriptional targets in human PH and the therapeutic potential of isoform-selective enzyme modulation are lacking. Comprehensive analysis of expression and regulation of class I HDACs...

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Share to Histone Deacetylase Inhibitors Research
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PMID: 32733053
DOI: 10.1038/s41598-020-69737-x

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