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Histone deacetylases in myocardial infarction: Orchestrating programmed cell death pathways and emerging therapeutic opportunities

25 Jul 2025

Abstract excerpt

Myocardial infarction (MI) remains a major global health challenge, characterized by irreversible cardiomyocyte loss primarily mediated by multiple programmed cell death (PCD) pathways - including apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis. Histone deacetylases (HDACs) have emerged as pivotal epigenetic regulators orchestrating these diverse PCD processes by modulating the acetylation status...

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PMID: 40714523
DOI: 10.1016/j.biopha.2025.118367

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