Article

Computational model of the full-length TSH receptor

2022-07-15

Abstract excerpt

The receptor for thyroid stimulating hormone (TSHR), a GPCR, is of particular interest as the primary antigen in autoimmune hyperthyroidism (Graves’ disease) caused by stimulating TSHR antibodies. To date, only one domain of the extracellular region of the TSHR has been crystallized. We have now generated a model of the entire TSHR by merging the extracellular region of the receptor, obtained using artificial inte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07747c14-13cb-5eea-8566-1b8a666b5d04
DOI: 10.1101/2022.07.13.499955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational model of the full-length TSH receptorDOI 10.1101/2022.07.13.499955Read

Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.Semantic proximity Read

Transmembrane domains of attraction on the TSH receptor.Semantic proximity Read

Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin ReceptorSemantic proximity Read

Minireview: Structural and Functional Evolution of the Thyrotropin ReceptorSemantic proximity Read

Novel insights on thyroid-stimulating hormone receptor signal transduction.Semantic proximity Read

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.Semantic proximity Read

Graves' Disease: In Silico Design of Hybrid Molecule Targeting the Thyroid-stimulating Hormone ReceptorSemantic proximity Read

Defining structural and functional dimensions of the extracellular thyrotropin receptor region.Semantic proximity Read

Molecular Investigation of TSHR gene in Bangladeshi Congenital Hypothyroid patientsSemantic proximity Read

Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody.Semantic proximity Read

Understanding the thyrotropin receptor function-structure relationship.Semantic proximity Read

Thyrotropin and Homologous Glycoprotein Hormone Receptors: Structural and Functional Aspects of Extracellular Signaling MechanismsSemantic proximity Read