Article
Novel insights on thyroid-stimulating hormone receptor signal transduction.
Endocrine reviews - 1 Oct 2013
Kleinau Gunnar, Neumann Susanne, Grüters Annette, Krude Heiko, Biebermann Heike
Abstract excerpt
The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSHR is of great importance for the growth and function of the thyroid gland. The TSHR and its endogenous ligand TSH are pivotal proteins with respect to a variety of physiological functions and malfunctions. The molecular events of TSHR regulation can be summarized as a process of...
Topics
- Amino Acids
- Binding Sites
- Cell Membrane
- GTP-Binding Proteins
- Gene Expression
- Genetic Variation
- Humans
- Molecular Structure
- Mutation
- Phenotype
- Protein Conformation
- Receptors, Thyrotropin
- Signal Transduction
- Thyroid Diseases