Minireview: Structural and Functional Evolution of the Thyrotropin Receptor

Abstract excerpt

TSH receptor (TSHR) is a member of the leucine-rich repeat-containing G protein-coupled receptors. Both TSHR and its ligand TSH have evolved to acquire specificity, minimize cross-reaction to other glycoprotein hormone receptors, and modulate cognate interaction (and thereby thyrotropic activity). TSHR sequences available from two life orders, teleost and mammals, were analyzed. Teleost TSHRs with low affinity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hypothalamic control of reproductive hormones
• Share to Neuropeptides and Animal Physiology
• Share to Receptor Mechanisms and Signaling