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Article

Defining structural and functional dimensions of the extracellular thyrotropin receptor region.

The Journal of biological chemistry - 24 Jun 2011

Kleinau Gunnar, Mueller Sandra, Jaeschke Holger, Grzesik Paul, Neumann Susanne, Diehl Anne, Paschke Ralf, Krause Gerd

Abstract excerpt

The extracellular region of the thyrotropin receptor (TSHR) can be subdivided into the leucine-rich repeat domain (LRRD) and the hinge region. Both the LRRD and the hinge region interact with thyrotropin (TSH) or autoantibodies. Structural data for the TSHR LRRD were previously determined by crystallization (amino acids Glu(30)-Thr(257), 10 repeats), but the structure of the hinge region is still undefined. Of...

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Identifiers

PMID: 21525003
DOI: 10.1074/jbc.M110.211193
PMCID: PMC3121406

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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