Article
Understanding the thyrotropin receptor function-structure relationship.
Bailliere's clinical endocrinology and metabolism - 1 Oct 1997
Sanders J, Oda Y, Roberts S A, Maruyama M, Furmaniak J, Smith B R
Abstract excerpt
The thyrotropin (TSH) receptor (TSHR) is a key protein in the control of thyroid function and a major thyroid autoantigen. Recently, molecular cloning of the receptor has been carried out and we now review the impact of this work on our understanding of the physiology and pathophysiology of the TSHR. Analysis of recombinant TSHR proteins expressed in prokaryotic and eukaryotic systems has indicated that...
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