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Article

Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.

The Journal of biological chemistry - 1 Jul 2016

Schaarschmidt Joerg, Nagel Marcus B M, Huth Sandra, Jaeschke Holger, Moretti Rocco, Hintze Vera, von Bergen Martin, Kalkhof Stefan, Meiler Jens, Paschke Ralf

Abstract excerpt

The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by binding of the hormone ligand TSH to the ECD. How the extracellular binding event triggers the conformational changes in the transmembrane domain (TMD) necessary for intracellular G protein activation is poorly understood. To gain insight in...

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Source

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Identifiers

PMID: 27129207
DOI: 10.1074/jbc.M115.709659
PMCID: PMC4933169

Genes

ECD
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.PMID 27129207Read ↗

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