Article

A Reproducibility Focused Meta-Analysis Method for Single-Cell Transcriptomic Case-Control Studies Uncovers Robust Differentially Expressed Genes

2024-10-16

Abstract excerpt

We assessed the reproducibility of differentially expressed genes (DEGs) in previously published Alzheimer’s (AD), Parkinson’s (PD), Huntington’s (HD), Schizophrenia (SCZ), and COVID-19 scRNA-seq studies. While transcriptional scores from DEGs of individual PD, HD, and COVID-19 datasets had moderate predictive power for case-control status of other datasets, genes from individual AD and SCZ datasets had poor predi...

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Literature Corpus work: 074d5922-ced7-5931-8e94-6556e85524fb
DOI: 10.1101/2024.10.15.618577

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