Meta‐Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross‐Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross‐Study Heterogeneity

Abstract excerpt

The comprehensive genome-wide nature of transcriptome studies in Alzheimer's disease (AD) should provide a reliable description of disease molecular states. However, the genes and molecular systems nominated by transcriptomic studies do not always overlap. Even when results do align, it is not clear if those observations represent true consensus across many studies. A couple of sources of variation have been...

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