Article

Directional Gene-Level Concordance and Methodological Constraints in Blood Transcriptomic and DNA Methylation Studies of Parkinson’s Disease

2026-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Assessing reproducibility across different molecular profiling studies is a persistent methodological challenge (Zhang et al., 2009; Sweeney et al., 2017; Ioannidis, 2005). Differences in platform technology, cohort composition, analytical pipelines, and feature definitions often make it difficult to interpret cross-study comparisons based solely on gene-identity overlap. In this study, we condu...

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Literature Corpus work: 803b3110-955e-5113-9075-101ba6a46ae4
DOI: 10.64898/2026.05.17.725808

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