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Article

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia.

Cell reports - 23 Jun 2020

Swarup Vivek, Chang Timothy S, Duong Duc M, Dammer Eric B, Dai Jingting, Lah James J, Johnson Erik C B, Seyfried Nicholas T, Levey Allan I, Geschwind Daniel H

Abstract excerpt

Data-driven analyses are increasingly valued in modern medicine. We integrate quantitative proteomics and transcriptomics from over 1,000 post-mortem brains from six cohorts representing Alzheimer's disease (AD), asymptomatic AD, progressive supranuclear palsy (PSP), and control patients from the Accelerating Medicines Partnership - Alzheimer's Disease consortium. We define robust co-expression trajectories...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32579933
DOI: 10.1016/j.celrep.2020.107807
PMCID: PMC8221021

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