Article

Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences

2020-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER) positive breast cancer. In this study, we performed DNA/RNA hybrid-capture sequencing on 12 locoregional recurrences after long-term estrogen-deprivation along with each tumor’s matched primary. Despite being up to 7 years removed from the primary lesion, most recurrences harbored similar intrinsic transcriptional and...

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Literature Corpus work: 07484b43-7a67-514a-b67e-3e342c0c525f
DOI: 10.1101/2020.06.08.140707

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