Article

Hotspot <i>ESR1</i> mutations are multimodal and contextual drivers of breast cancer metastasis

2021-02-11

Abstract excerpt

Constitutively active estrogen receptor-α (ER/ ESR1 ) mutations have been identified in approximately one third of ER+ metastatic breast cancer. Although these mutations are known mediators of endocrine resistance, their potential role in promoting metastatic disease has not yet been mechanistically addressed. In this study, we show the presence of ESR1 mutations exclusively in distant, but not local recurrences...

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Literature Corpus work: 126b2e57-58bb-56ef-adc5-71602f64c9d2
DOI: 10.1101/2021.02.10.430701

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