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Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases

6 Sept 2017

Abstract excerpt

Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen receptor-positive (ER-positive) breast cancer; yet, characterizations of human specimens are limited. In this study, exome-capture RNA sequencing (ecRNA-seq) on aged (8-12 years), formalin-fixed, paraffin-embedded (FFPE), and decalcified cancer specimens was evaluated. Gene expression values and ecRNA-seq quality metrics from...

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PMID: 28878133
DOI: 10.1172/jci.insight.95703

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