Article

Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers

2021-08-30

Abstract excerpt

<title>Abstract</title> <p>Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). We performed multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify potential recurrence-specific drivers. <italic>PARP1</italic> amplifications were identified in recurrences (FDR q = 0.05), and PARP1 was signi...

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Literature Corpus work: 4ca6e008-e5b9-5551-bc5b-f9ff5cdb23bc
DOI: 10.21203/rs.3.rs-745248/v1

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