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Article

Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences.

Breast cancer research : BCR - 6 Jan 2021

Priedigkeit Nolan, Ding Kai, Horne William, Kolls Jay K, Du Tian, Lucas Peter C, Blohmer Jens-Uwe, Denkert Carsten, Machleidt Anna, Ingold-Heppner Barbara, Oesterreich Steffi, Lee Adrian V

Abstract excerpt

BACKGROUND: Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-positive breast cancer. In this study, we aimed to determine acquired genomic changes in endocrine-resistant disease. METHODS: We performed DNA/RNA hybrid-capture sequencing on 12 locoregional recurrences after long-term estrogen deprivation and identified acquired genomic changes versus each tumor's matched primary....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33407744
DOI: 10.1186/s13058-020-01379-3
PMCID: PMC7788918

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