Article
Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2017
Chung J H, Pavlick D, Hartmaier R, Schrock A B, Young L, Forcier B, Ye P, Levin M K, Goldberg M, Burris H, Gay L M, Hoffman A D, Stephens P J, Frampton G M, Lipson D M, Nguyen D M, Ganesan S, Park B H, Vahdat L T, Leyland-Jones B, Mughal T I, Pusztai L, O'Shaughnessy J, Miller V A, Ross J S, Ali S M
Abstract excerpt
BACKGROUND: Genomic changes that occur in breast cancer during the course of disease have been informed by sequencing of primary and metastatic tumor tissue. For patients with relapsed and metastatic disease, evolution of the breast cancer genome highlights the importance of using a recent sample for genomic profiling to guide clinical decision-making. Obtaining a metastatic tissue biopsy can be challenging, and...
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