Article

Reversal of elevated <i>Gli3</i> in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesis

2024-09-22

Abstract excerpt

Polycystic kidney diseases (PKD) are genetic disorders characterised by the formation of fluid-filled cysts, which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). Prior studies have implicated the ciliary-located Hedgehog (Hh) pathway in ADPKD, with increas...

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Literature Corpus work: 956ceb97-dc53-565d-b8f7-51f61fe94b31
DOI: 10.1101/2024.09.18.613676

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Reversal of elevated <i>Gli3</i> in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesisDOI 10.1101/2024.09.18.613676Read

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