Article
Polycystic kidney disease in the medaka (Oryzias latipes) pc mutant caused by a mutation in the Gli-Similar3 (glis3) gene.
PloS one - 17 Jul 2009
Hashimoto Hisashi, Miyamoto Rieko, Watanabe Naoki, Shiba Dai, Ozato Kenjiro, Inoue Chikako, Kubo Yuko, Koga Akihiko, Jindo Tomoko, Narita Takanori, Naruse Kiyoshi, Ohishi Kazuko, Nogata Keiko, Shin-I Tadasu, Asakawa Shuichi, Shimizu Nobuyoshi, Miyamoto Tomotsune, Mochizuki Toshio, Yokoyama Takahiko, Hori Hiroshi, Takeda Hiroyuki, Kohara Yuji, Wakamatsu Yuko
Abstract excerpt
Polycystic kidney disease (PKD) is a common hereditary disease in humans. Recent studies have shown an increasing number of ciliary genes that are involved in the pathogenesis of PKD. In this study, the Gli-similar3 (glis3) gene was identified as the causal gene of the medaka pc mutant, a model of PKD. In the pc mutant, a transposon was found to be inserted into the fourth intron of the pc/glis3 gene, causing...
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