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Article

Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.

The Journal of clinical investigation - 1 Feb 2002

Hou Xiaoying, Mrug Michal, Yoder Bradley K, Lefkowitz Elliot J, Kremmidiotis Gabriel, D'Eustachio Peter, Beier David R, Guay-Woodford Lisa M

Abstract excerpt

The congenital polycystic kidney (cpk) mutation is the most extensively characterized mouse model of polycystic kidney disease (PKD). The renal cystic disease is fully expressed in homozygotes and is strikingly similar to human autosomal recessive PKD (ARPKD), whereas genetic background modulates the penetrance of the corresponding defect in the developing biliary tree. We now describe the positional cloning,...

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Share to Cilia
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Homozygote

Share to Mice, Inbred DBA

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Share to Mice, Mutant Strains

Share to Polycystic Kidney, Autosomal Dominant

Source

Open in PubMed Open full text

Identifiers

PMID: 11854326
DOI: 10.1172/JCI14099
PMCID: PMC150876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.PMID 11854326Read ↗

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