NovumRNA: accurate prediction of non-canonical tumor antigens from RNA sequencing data

Abstract excerpt

<h4>Summary</h4> Non-canonical tumor-specific antigens (ncTSAs) can expand the pool of targets for cancer immunotherapy, but require robust and comprehensive computational pipelines for their prediction. Here, we present NovumRNA, a fully-automated Nextflow pipeline for predicting different classes of ncTSAs from patients’ RNA sequencing data. We extensively validated NovumRNA using publicly-available and newly-g...

Topics

Open a Topic to create a Post that cites this publication.

• Antigens, Neoplasm
• Esophageal Neoplasms
• Esophageal Squamous Cell Carcinoma
• Machine Learning
• Microsatellite Instability
• Mutation
• Reproducibility of Results
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

c9375013-1381-508d-b67a-edf9160804ce

DOI

10.1101/2024.11.05.622043