Article

SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell Transcriptomics

2025-01-22

Abstract excerpt

<h4>Summary</h4> The FDA approval of T cell receptor-engineered T cells (TCR-T) for synovial sarcoma demonstrates the potential for adoptive T cell therapies (ACTs) in solid tumors. However, the paucity of tumor-specific targets without expression in normal tissues remains a major bottleneck, especially in rare cancer subtypes. Here, we present a comprehensive computational pipeline called SCAN-ACT that leverages...

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Literature Corpus work: a9af66a3-ac99-5c76-b710-daa7d11b539e
DOI: 10.1101/2025.01.18.633736

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